Disease is natural and unavoidable. Today’s global order, however, produces epidemiological environments that favor the accelerated spread of both infectious and chronic disease. The current pandemic is a case in point. Rather than focusing on it narrowly, let us look into the mirror of COVID-19. It reflects defaunation Big wild animals, freshwater animals, amphibians and reptiles, marine animals, all manner of birds, insects, the anonymous of the tropics, and others are experiencing species extinctions, population drops, and range contractions. The holocaust of animals leaves behind “empty world syndrome.”